CLINICAL
INNOVATIONS

Once an understanding of the role of mitochondrial dysfunction in disease is established, several possibilities for assessment, in addition to standard diagnostics, are made available.

MITOCHONDRIAL FUNCTION PROFILE

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MITOCHONDRIAL FUNCTION PROFILE

This blood test combines several tests which together assess mitochondrial function and identify where the problem areas with energy production are. It is exceptionally useful for chronic fatigue sufferers as it gives clear indications for a treatment regime.

Mitochondrial function profile is made up of the following individual tests:

  • ATP profiles;
  • NAD (functional B3);
  • SODase;
  • L-carnitine;
  • Cell-free DNA;
  • Glutathione Peroxidase.

OPEN RESPIROMETRY

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OPEN RESPIROMETRY

The third tool used in our research is known as open respirometry. Typically this is a tool used in testing athletic performance where exercise is performed while breathing into a mask which collects gas output for analysis. With chronic conditions oxygen consumption and CO2 production are very good measures of energy metabolism in general. Any chronic disease with impaired metabolism and oxidative stress as symptoms will show major alterations in oxygen utilization.


Mitochondria

HYDROPEROXIDE ANALYSIS

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HYDROPEROXIDE ANALYSIS

The role of Hydrogen Peroxide as a signalling molecule is fundamental to assessing the restoration of mitochondrial function.

FRAS (free radical analysis system) is an integrated analytical system consisting of a dedicated photometer with an incorporated centrifuge, designed to allow the global assessment of hydroperoxides and plasma antioxidant levels, both of which are fundamental to understanding the effects of the BX Protocol in restoring homeostasis between free radicals and oxygen metabolites.

CRENATION STUDIES

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CRENATION STUDIES

The second tool used in this research is known as crenation testing. The purpose of crenation testing is to test the viability of high energy proteins in the cell wall. These proteins consume about 40% of the energy produced in a cell. When energy metabolism is impaired these proteins lack the energy needed to perform their function. By subjecting the cells to a special solution we can observe the behavior of the cell and determine how much energy is being produced. A normal cell will shrivel in this solution, while an impaired cell will actually swell.  The goal of this testing is to achieve 100% crenation. Patients of the BX typically go from 50% to 99% crenation.

INNOVATIVE
MITOCHONDRIAL
ASSESSMENTS

Measures Matter! And knowing
what and where to measure is
critical to success.